Structural highlights
Function
POF8_SCHPO RNA-binding protein required for assembly of the holoenzyme telomerase ribonucleoprotein (RNP) complex (PubMed:29422501, PubMed:29422503, PubMed:29422664). Specifically binds telomerase RNA ter1 and promotes assembly of ter1 with catalytic subunit trt1 (PubMed:29422501, PubMed:29422503). Telomerase is a ribonucleoprotein enzyme essential that copies new telomeric repeats onto chromosome ends and functions to maintain cell division (PubMed:29422501, PubMed:29422503, PubMed:29422664).[1] [2] [3]
References
- ↑ Collopy LC, Ware TL, Goncalves T, I Kongsstovu S, Yang Q, Amelina H, Pinder C, Alenazi A, Moiseeva V, Pearson SR, Armstrong CA, Tomita K. LARP7 family proteins have conserved function in telomerase assembly. Nat Commun. 2018 Feb 8;9(1):557. doi: 10.1038/s41467-017-02296-4. PMID:29422501 doi:https://dx.doi.org/10.1038/s41467-017-02296-4
- ↑ Mennie AK, Moser BA, Nakamura TM. LARP7-like protein Pof8 regulates telomerase assembly and poly(A)+TERRA expression in fission yeast. Nat Commun. 2018 Feb 8;9(1):586. doi: 10.1038/s41467-018-02874-0. PMID:29422503 doi:https://dx.doi.org/10.1038/s41467-018-02874-0
- ↑ Paez-Moscoso DJ, Pan L, Sigauke RF, Schroeder MR, Tang W, Baumann P. Pof8 is a La-related protein and a constitutive component of telomerase in fission yeast. Nat Commun. 2018 Feb 8;9(1):587. doi: 10.1038/s41467-017-02284-8. PMID:29422664 doi:https://dx.doi.org/10.1038/s41467-017-02284-8
