6u79

Solution NMR structure of 5' UTR stem loop B from West Nile Virus

spinqualitylabelsall models 6u79 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6u79 is a 1 chain structure with sequence from West Nile virus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Flaviviruses are major emerging human pathogenic viruses that pose a persistent and growing menace to global health. They are enveloped single-stranded RNA viruses with positive polarity transmitted by arthropod vectors like mosquitoes or ticks, responsible for a significant and growing number of human deaths and illnesses. The 5'- and 3'-untranslated regions (UTRs) are highly structured and contain conserved cis-acting RNA elements that participate in viral translation, replication and host adaptation. Despite their role in fiaviviruses replication, few high-resolution structural studies have investigated the RNA elements required for viral replication. Here we report the NMR structures of stem-loop B from WNV and DENV4 viruses. Because this element is required for cyclization of the genome and the activity of the replicative viral enzymes, viral replication rates are sensitive to even small changes in these RNAs. Therefore, this work provides structural insight into a new drug target to reduce flavivirus replication rates. NMR structure of Dengue West Nile viruses stem-loop B: A key cis-acting element for flavivirus replication.,Sharma S, Varani G Biochem Biophys Res Commun. 2020 Aug 15. pii: S0006-291X(20)31512-6. doi:, 10.1016/j.bbrc.2020.07.115. PMID:32807496 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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