6ubl

Structure of DynF from the Dynemicin Biosynthesis Pathway of Micromonospora chersina

spinqualitylabelsall models 6ubl, resolution 1.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6ubl is a 2 chain structure with sequence from Micromonospora chersina. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.499Å Ligands: PLM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B2BM43_9ACTN Publication Abstract from PubMed Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core. The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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