Structural highlights
Function
PE25_MYCTU The PE25/PPE41 dimer induces both a strong humoral and cellular immune response. PE25 protein alone induces low response (PubMed:18974870). The dimer induces necrosis, but not apoptosis, in mouse macrophage cells (PubMed:25379378). It also induces activation and maturation of mouse dendritic cells and drives Th2-biased immune responses (PubMed:26318856).[1] [2] [3]
References
- ↑ Tundup S, Pathak N, Ramanadham M, Mukhopadhyay S, Murthy KJ, Ehtesham NZ, Hasnain SE. The co-operonic PE25/PPE41 protein complex of Mycobacterium tuberculosis elicits increased humoral and cell mediated immune response. PLoS One. 2008;3(10):e3586. doi: 10.1371/journal.pone.0003586. Epub 2008 Oct 31. PMID:18974870 doi:https://dx.doi.org/10.1371/journal.pone.0003586
- ↑ Tundup S, Mohareer K, Hasnain SE. Mycobacterium tuberculosis PE25/PPE41 protein complex induces necrosis in macrophages: Role in virulence and disease reactivation? FEBS Open Bio. 2014 Sep 16;4:822-8. doi: 10.1016/j.fob.2014.09.001. eCollection , 2014. PMID:25379378 doi:https://dx.doi.org/10.1016/j.fob.2014.09.001
- ↑ Chen W, Bao Y, Chen X, Burton J, Gong X, Gu D, Mi Y, Bao L. Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses. Med Microbiol Immunol. 2016 Apr;205(2):119-31. doi: 10.1007/s00430-015-0434-x. , Epub 2015 Aug 30. PMID:26318856 doi:https://dx.doi.org/10.1007/s00430-015-0434-x
