6wsa | pdb_00006wsa

Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei without cofactor

spinqualitylabelsall models 6wsa, resolution 2.05Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6wsa is a 1 chain structure with sequence from Burkholderia pseudomallei 1710b. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.05Å Ligands: EDO, NA, SIN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function BETB_BURP1 Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the irreversible oxidation of betaine aldehyde to the corresponding acid.[HAMAP-Rule:MF_00804] Publication Abstract from PubMed Burkholderia pseudomallei infection causes melioidosis, which is often fatal if untreated. There is a need to develop new and more effective treatments for melioidosis. This study reports apo and cofactor-bound crystal structures of the potential drug target betaine aldehyde dehydrogenase (BADH) from B. pseudomallei. A structural comparison identified similarities to BADH from Pseudomonas aeruginosa which is inhibited by the drug disulfiram. This preliminary analysis could facilitate drug-repurposing studies for B. pseudomallei. Crystal structure of betaine aldehyde dehydrogenase from Burkholderia pseudomallei.,Beard DK, Subramanian S, Abendroth J, Dranow DM, Edwards TE, Myler PJ, Asojo OA Acta Crystallogr F Struct Biol Commun. 2022 Feb 1;78(Pt 2):45-51. doi:, 10.1107/S2053230X21013455. Epub 2022 Jan 27. PMID:35102892 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Aldehyde dehydrogenase 3D structures

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