Structural highlights
FunctionA0A1S3TVC7_VIGRR Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.[ARBA:ARBA00003195] Publication Abstract from PubMedRespiration, an essential metabolic process, provides cells with chemical energy. In eukaryotes, respiration occurs via the mitochondrial electron transport chain (mETC) composed of several large membrane-protein complexes. Complex I (CI) is the main entry point for electrons into the mETC. For plants, limited availability of mitochondrial material has curbed detailed biochemical and structural studies of their mETC. Here, we present the cryoEM structure of the known CI assembly intermediate CI* from Vigna radiata at 3.9 A resolution. CI* contains CI's NADH-binding and CoQ-binding modules, the proximal-pumping module and the plant-specific gamma-carbonic-anhydrase domain (gammaCA). Our structure reveals significant differences in core and accessory subunits of the plant complex compared to yeast, mammals and bacteria, as well as the details of the gammaCA domain subunit composition and membrane anchoring. The structure sheds light on differences in CI assembly across lineages and suggests potential physiological roles for CI* beyond assembly. Atomic structure of a mitochondrial complex I intermediate from vascular plants.,Maldonado M, Padavannil A, Zhou L, Guo F, Letts JA Elife. 2020 Aug 25;9:e56664. doi: 10.7554/eLife.56664. PMID:32840211[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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