6xcl

Crystal Structure of human telomeric DNA G-quadruplex in complex with a novel platinum(II) complex.

spinqualitylabelsall models 6xcl, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.7Å Ligands: EDO, K, V4A Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Guanine quadruplex recognition has gained increasing attention, inspired by the growing awareness of the key roles played by these non-canonical nucleic acid architectures in cellular regulatory processes. We report here the solution and solid-state studies of a novel planar platinum(II) complex that is easily assembled from a simple ligand, and exhibits notable binding affinity for guanine quadruplex structures, while maintaining good selectivity for guanine quadruplex over duplex structures. A crystal structure of this ligand complexed with a telomeric quadruplex confirms double end-capping, with dimerization at the 5' interface. Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution- and Solid-State Investigations.,Miron CE, van Staalduinen L, Rangaswamy AMM, Chen M, Liang Y, Jia Z, Mergny JL, Petitjean A Angew Chem Int Ed Engl. 2020 Oct 22. doi: 10.1002/anie.202012520. PMID:33090592 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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