6xwx

Crystal structure of the Tof1-Csm3 complex

spinqualitylabelsall models 6xwx, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6xwx is a 6 chain structure with sequence from Chaetomium thermophilum var. thermophilum DSM 1495. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.1Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G0S825_CHATD Publication Abstract from PubMed The Tof1-Csm3 fork protection complex has a central role in the replisome-it promotes the progression of DNA replication forks and protects them when they stall, while also enabling cohesion establishment and checkpoint responses. Here, I present the crystal structure of the Tof1-Csm3 complex from Chaetomium thermophilum at 3.1 A resolution. The structure reveals that both proteins together form an extended alpha helical repeat structure, which suggests a mechanical or scaffolding role for the complex. Expanding on this idea, I characterize a DNA interacting region and a cancer-associated Mrc1 binding site. This study provides the molecular basis for understanding the functions of the Tof1-Csm3 complex, its human orthologue the Timeless-Tipin complex and additionally the Drosophila circadian rhythm protein Timeless. Crystal structure and interactions of the Tof1-Csm3 (Timeless-Tipin) fork protection complex.,Grabarczyk DB Nucleic Acids Res. 2020 May 29. pii: 5848492. doi: 10.1093/nar/gkaa456. PMID:32469068 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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