6xxw

Structure of beta-D-Glucuronidase for Dictyoglomus thermophilum.

spinqualitylabelsall models 6xxw, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6xxw is a 1 chain structure with sequence from Dictyoglomus thermophilum H-6-12. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.851Å Ligands: CL, MPD, TRS Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B5YFE0_DICT6 Publication Abstract from PubMed The beta-d-glucuronidase DtGlcA from Dictyoglomus thermophilum was engineered to generate an active thioglycoligase that is able to catalyse the formation of numerous S-glucuronides. Its X-ray structure analysis indicated the ability of the biocatalyst to bind aromatic thiol acceptors for S-glycosylation. Noteworthily, the DtGlcA mutant was found to be the first thioligase that is able to use a natural sugar donor different from the widely used synthetic para-nitrophenyl glycosides. Thioglycoligation of aromatic thiols using a natural glucuronide donor.,Kurdziel M, Kopec M, Paris A, Lewinski K, Lafite P, Daniellou R Org Biomol Chem. 2020 Jul 16. doi: 10.1039/d0ob00226g. PMID:32671369 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glucuronisidase 3D structures

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