6y0k

Sulfite oxidase from Thermus thermophilus with coordinated phosphate

spinqualitylabelsall models 6y0k, resolution 1.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6y0k is a 1 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.7Å Ligands: GOL, MSS, PO4 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5SIP4_THET8 Publication Abstract from PubMed By combining X-ray crystallography, electron paramagnetic resonance techniques and density functional theory-based modelling, we provide evidence for a direct coordination of the product analogue, phosphate, to the molybdenum active site of a sulfite dehydrogenase. This interaction is mimicking the still experimentally uncharacterized reaction intermediate proposed to arise during the catalytic cycle of this class of enzymes. This work opens new perspectives for further deciphering the reaction mechanism of this nearly ubiquitous class of oxidoreductases. Structural evidence for a reaction intermediate mimic in the active site of a sulfite dehydrogenase.,Djeghader A, Rossotti M, Abdulkarim S, Biaso F, Gerbaud G, Nitschke W, Schoepp-Cothenet B, Soulimane T, Grimaldi S Chem Commun (Camb). 2020 Jul 27. doi: 10.1039/d0cc03634j. PMID:32716419 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Sulfite Oxidase

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