6yep

LNA modified G-quadruplex with flipped G-tract and central tetrad

spinqualitylabelsall models 6yep, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6yep is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: LCG Related: 6ycv, 6f4z Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A hybrid-type G-quadruplex is modified with LNA (locked nucleic acid) and 2'-F-riboguanosine in various combinations at the two syn positions of its third antiparallel G-tract. LNA substitution in the central tetrad causes a complete rearrangement to either a V-loop or antiparallel structure, depending on further modifications at the 5'-neighboring site. In the two distinct structural contexts, LNA-induced stabilization is most effective compared to modifications with other G surrogates, highlighting a potential use of LNA residues for designing not only parallel but various more complex G4 structures. For instance, the conventional V-loop is a structural element strongly favored by an LNA modification at the V-loop 3'-end in contrast with an alternative V-loop, clearly distinguishable by altered conformational properties and base-backbone interactions as shown in a detailed analysis of V-loop structures. Locked nucleic acid building blocks as versatile tools for advanced G-quadruplex design.,Haase L, Weisz K Nucleic Acids Res. 2020 Sep 5. pii: 5901961. doi: 10.1093/nar/gkaa720. PMID:32890406 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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