Structural highlights
6ygf is a 2 chain structure with sequence from Aspergillus fumigatus Af293. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Method: | X-ray diffraction, Resolution 1.7Å |
| Ligands: | AR6, BMA, FUC, GOL, MAN, NAG, NCA, PO4 |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
NADA_ASPFU Conidial surface nicotinamide adenine dinucleotide glycohydrolase that cleave NAD(+) and NADP(+) but not their reduced counterparts, NADH and NADPH (PubMed:33712585). Lacks both ADP-ribosyl cyclase and base exchange activity and does not mediate synthesis of calcium messengers cADPR or NAADP (PubMed:33712585). Plays a role in pathogenicity by depleting the host's NAD(+) pool (PubMed:33712585).[1]
References
- ↑ Stromland O, Kallio JP, Pschibul A, Skoge RH, Harethardottir HM, Sverkeli LJ, Heinekamp T, Kniemeyer O, Migaud M, Makarov MV, Gossmann TI, Brakhage AA, Ziegler M. Discovery of fungal surface NADases predominantly present in pathogenic species. Nat Commun. 2021 Mar 12;12(1):1631. doi: 10.1038/s41467-021-21307-z. PMID:33712585 doi:https://dx.doi.org/10.1038/s41467-021-21307-z
