6yxe

Structure of the Trim69 RING domain

spinqualitylabelsall models 6yxe, resolution 2.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6yxe is a 2 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: ZN Gene: TRIM69, RNF36, HSD-34, HSD34 (HUMAN) Activity: RING-type E3 ubiquitin transferase, with EC number 2.3.2.27 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [TRI69_HUMAN] May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis. Publication Abstract from PubMed Members of the TRIM protein family have been shown to inhibit a range of viral infections. Recently, TRIM69 was identified as a potent inhibitor of Vesicular stomatitis Indiana virus infection, with its inhibition being dependent upon multimerization. Using SEC-MALLS analysis, it is demonstrated that the assembly of TRIM69 is mediated through the RING domain and not the Bbox domain as has been shown for other TRIM proteins. Using X-ray crystallography, the structure of the TRIM69 RING domain has been determined to a resolution of 2.1 A, the oligomerization interface has been identified and regions outside the four-helix bundle have been observed to form interactions that are likely to support assembly. The RING domain of TRIM69 promotes higher-order assembly.,Keown JR, Yang J, Black MM, Goldstone DC Acta Crystallogr D Struct Biol. 2020 Oct 1;76(Pt 10):954-961. doi:, 10.1107/S2059798320010499. Epub 2020 Sep 16. PMID:33021497 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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