6zc7

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

spinqualitylabelsall models 6zc7, resolution 1.48Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 6zc7 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.48Å Ligands: V31 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease DVL3_HUMAN Autosomal dominant Robinow syndrome. The disease is caused by variants affecting the gene represented in this entry. Function DVL3_HUMAN Involved in the signal transduction pathway mediated by multiple Wnt genes.[UniProtKB:Q61062]

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