7a62

Structure of human indoleamine-2,3-dioxygenase 1 (hIDO1) with a complete JK loop

spinqualitylabelsall models 7a62, resolution 2.44Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.4379644Å Ligands: CL, GOL, HEM Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Indoleamine 2,3-dioxygenase 1 has sparked interest as an immunotherapeutic target in cancer research. Its structure includes a loop, named the JK-loop, that controls the orientation of the substrate or inhibitor within the active site. However, little has been reported about the crystal structure of this loop. In the present work, the conformation of the JK-loop is determined for the first time in the presence of the heme cofactor in the active site through X-ray diffraction experiments (2.44 A resolution). Molecular-dynamics trajectories were also obtained to provide dynamic information about the loop according to the presence of cofactor. This new structural and dynamic information highlights the importance of the JK-loop in confining the labile heme cofactor to the active site. Influence of the presence of the heme cofactor on the JK-loop structure in indoleamine 2,3-dioxygenase 1.,Mirgaux M, Leherte L, Wouters J Acta Crystallogr D Struct Biol. 2020 Dec 1;76(Pt 12):1211-1221. doi:, 10.1107/S2059798320013510. Epub 2020 Nov 19. PMID:33263327 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Dioxygenase 3D structures

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