7b7j

EccD5 ubiqutin like domain from Mycobacterium xenopi

spinqualitylabelsall models 7b7j, resolution 1.66Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7b7j is a 1 chain structure with sequence from Mycobacterium xenopi. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.66Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function I0RSS8_MYCXE Publication Abstract from PubMed The ESX-5 type VII secretion system is a membrane-spanning protein complex key to the virulence of mycobacterial pathogens. However, the overall architecture of the fully assembled translocation machinery and the composition of the central secretion pore have remained unknown. Here, we present the high-resolution structure of the 2.1-megadalton ESX-5 core complex. Our structure captured a dynamic, secretion-competent conformation of the pore within a well-defined transmembrane section, sandwiched between two flexible protein layers at the cytosolic entrance and the periplasmic exit. We propose that this flexibility endows the ESX-5 machinery with large conformational plasticity required to accommodate targeted protein secretion. Compared to known secretion systems, a highly dynamic state of the pore may represent a fundamental principle of bacterial secretion machineries. Structure of the mycobacterial ESX-5 type VII secretion system pore complex.,Beckham KSH, Ritter C, Chojnowski G, Ziemianowicz DS, Mullapudi E, Rettel M, Savitski MM, Mortensen SA, Kosinski J, Wilmanns M Sci Adv. 2021 Jun 25;7(26). pii: 7/26/eabg9923. doi: 10.1126/sciadv.abg9923., Print 2021 Jun. PMID:34172453 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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