7bfs

deoxyxylose nucleic acid hairpin

spinqualitylabelsall models 7bfs, 10 NMR models Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7bfs is a 1 chain structure. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. NonStd Res: XC Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Xenobiology explores synthetic nucleic acid polymers as alternative carriers of genetic information to expand the central dogma. The xylo- and deoxyxylo-nucleic acids (XyNA and dXyNA), containing 3' epimers of riboses and deoxyriboses, are considered as potential candidates for an orthogonal system. In this study, thermal and spectroscopic analysis show that XyNA and dXyNA form stable hairpins. The dXyNA hairpin structure determined by NMR spectroscopy contains a flexible loop that locks the stem in a stable ladder-like duplex with marginal right-handed helicity. Reduced flexibility of the dXyNA duplex observed in the stem of the hairpin demonstrates that folding of dXyNA yields more stable structures as described so far. Stable hairpin structures formed by xylose based nucleic acids.,Mattelaer CA, Maiti M, Smets L, Maiti M, Schepers G, Mattelaer HP, Rosemeyer H, Herdewijn P, Lescrinier E Chembiochem. 2021 Jan 11. doi: 10.1002/cbic.202000803. PMID:33427360 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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