7bur | pdb_00007bur

Chalcone synthase from Glycine max (L.) Merr (soybean) complexed with naringenin

spinqualitylabelsall models 7bur, resolution 1.82Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7bur is a 2 chain structure with sequence from Glycine max. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.82Å Ligands: CIT, CSD, NAR, SME Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CHS1_SOYBN The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. Publication Abstract from PubMed Isoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1. This article is protected by copyright. All rights reserved. Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.,Imaizumi R, Mameda R, Takeshita K, Kubo H, Sakai N, Nakata S, Takahashi S, Kataoka K, Yamamoto M, Nakayama T, Yamashita S, Waki T Proteins. 2020 Jul 29. doi: 10.1002/prot.25988. PMID:32725893 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Chalcone synthase

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