7c3k

Crystal Structure of mIRGB10

spinqualitylabelsall models 7c3k, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7c3k is a 2 chain structure with sequence from Mus musculus molossinus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.6Å Ligands: GDP Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q0GUM3_MOUSE Publication Abstract from PubMed Immunity-related GTPase B10 (IRGB10) belongs to the interferon (IFN)-inducible GTPases, a family of proteins critical to host defense. It is induced by IFNs after pathogen infection, and plays a role in liberating pathogenic ligands for the activation of the inflammasome by directly disrupting the pathogen membrane. Although IRGB10 has been intensively studied owing to its functional importance in the cell-autonomous immune response, the molecular mechanism of IRGB10-mediated microbial membrane disruption is still unclear. In this study, we report the structure of mouse IRGB10. Our structural study showed that IRGB10 bound to GDP forms an inactive head-to-head dimer. Further structural analysis and comparisons indicated that IRGB10 might change its conformation to activate its membrane-binding and disruptive functions. Based on this observation, we propose a model of the working mechanism of IRGB10 during pathogen membrane disruption. Molecular basis of IRGB10 oligomerization and membrane association for pathogen membrane disruption.,Ha HJ, Chun HL, Lee SY, Jeong JH, Kim YG, Park HH Commun Biol. 2021 Jan 19;4(1):92. doi: 10.1038/s42003-020-01640-7. PMID:33469160 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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