7c7i
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Crystal structure of SHANK3 SPN domain in complex with GTP-bound Rap1b(E30D,K31E)
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Structural highlights
FunctionRAP1B_HUMAN GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction.[1] [2] See AlsoReferences
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This page was last modified 15:58, 29 November 2023.