7cv3

Quadruplex-duplex hybrid structure in the PIM1 gene, Form 1

spinqualitylabelsall models 7cv3 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7cv3 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex-duplex hybrid (QDH) forming sequence was recently found to exist near the transcription start site of PIM1. This structure could be an attractive target for regulation of the PIM1 gene expression and thus the treatment of TNBC. Here, we present the solution structures of two QDHs that could coexist in the human PIM1 gene. Form 1 is a three-G-tetrad-layered (3+1) G-quadruplex containing a propeller loop, a lateral loop and a stem-loop made up of three G*C Watson-Crick base pairs. On the other hand, Form 2 is an anti-parallel G-quadruplex comprising two G-tetrads and a G*C*G*C tetrad; the structure has three lateral loops with the middle stem-loop made up of two Watson-Crick G*C base pairs. These structures provide valuable information for the design of G-quadruplex-specific ligands for PIM1 transcription regulation. Coexistence of two quadruplex-duplex hybrids in the PIM1 gene.,Tan DJY, Winnerdy FR, Lim KW, Phan AT Nucleic Acids Res. 2020 Sep 25. pii: 5911740. doi: 10.1093/nar/gkaa752. PMID:32976598 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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