7dd4

Solution structure of an RNA derived from the joint region of the TAR and PolyA stems of HIV-1 genomic RNA

spinqualitylabelsall models 7dd4 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7dd4 is a 1 chain structure with sequence from Human immunodeficiency virus 1. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The 5'-UTR of HIV-1 genomic RNA is known to form specific structures and has important functions. There are three 5'-terminal sequences, G1, G2 and G3, with different localizations in the cell and virion particles as well as different efficiencies in translation and reverse transcription reactions. In the present study, the structural characteristics of the joint region between the TAR and PolyA stems was analysed, and it was found that small differences in the 5'-terminus affect the conformational characteristics of the stem-loop structures. In the G1 form, the two stems form a coaxial stem, whereas in the G2 and G3 forms, the two stems are structurally independent of each other. In the case of the G1 form, the 3'-flanking nucleotides of the PolyA stem are included in the stable coaxial stem structure, which may affect the rest of the 5'-UTR structure. This result demonstrates that the local conformation of this functionally key region has an important role in the function of the 5'-UTR. Influence of the 5'-terminal sequences on the 5'-UTR structure of HIV-1 genomic RNA.,Obayashi CM, Shinohara Y, Masuda T, Kawai G Sci Rep. 2021 May 25;11(1):10920. doi: 10.1038/s41598-021-90427-9. PMID:34035384 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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