7dfy

Novel motif for left-handed G-quadruplex formation

spinqualitylabelsall models 7dfy, resolution 1.69Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7dfy is a 2 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.69Å Ligands: K, MPD, SR Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation. A novel minimal motif for left-handed G-quadruplex formation.,Das P, Winnerdy FR, Maity A, Mechulam Y, Phan AT Chem Commun (Camb). 2021 Mar 9;57(20):2527-2530. doi: 10.1039/d0cc08146a. PMID:33690751 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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