7efo

LptB2FG-LPS from Klebsiella pneumoniae in nanodiscs

spinqualitylabelsall models 7efo, resolution 3.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7efo is a 4 chain structure with sequence from Klebsiella pneumoniae subsp. pneumoniae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.85Å Ligands: JSG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A2X3II39_KLEPN Part of the ABC transporter complex LptBFG involved in the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane. Probably responsible for energy coupling to the transport system.[ARBA:ARBA00024818] Publication Abstract from PubMed Lipopolysaccharide (LPS) is an essential component of the outer membrane (OM) in most Gram-negative bacteria. LPS transport from the inner membrane (IM) to the OM is achieved by seven lipopolysaccharide transport proteins (LptA-G). LptB(2)FG, an type VI ATP-binding cassette (ABC) transporter, forms a stable complex with LptC, extracts LPS from the IM and powers LPS transport to the OM. Here we report the cryo-EM structures of LptB(2)FG and LptB(2)FGC from Klebsiella pneumoniae in complex with LPS. The KpLptB(2)FG-LPS structure provides detailed interactions between LPS and the transporter, while the KpLptB(2)FGC-LPS structure may represent an intermediate state that the transmembrane helix of LptC has not been fully inserted into the transmembrane domains of LptB(2)FG. Cryo-EM structures of LptB(2)FG and LptB(2)FGC from Klebsiella pneumoniae in complex with lipopolysaccharide.,Luo Q, Shi H, Xu X Biochem Biophys Res Commun. 2021 Sep 24;571:20-25. doi: , 10.1016/j.bbrc.2021.07.049. Epub 2021 Jul 21. PMID:34303191 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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