7emy

Pyochelin synthetase, a dimeric nonribosomal peptide synthetase elongation module

spinqualitylabelsall models 7emy, resolution 2.97Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7emy is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 2.97Å Ligands: AMP, CYS, MG, PNS, SAL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function PCHE_PSEAE Involved in the biosynthesis of the siderophore pyochelin (PubMed:9846750, PubMed:11208777). Accepts salicylate activated by PchD at the first peptidyl carrier domain (ArCP), and activates and fixes one molecule of cysteine at the second peptidyl carrier domain (PCP1) via a thioester linkage to the phosphopanthetheine moiety (By similarity). Then catalyzes the condensation reaction between the salicylate bound to the first site and the cysteine bound to the second site, and the cyclization of the cysteine to form the salicyl-thiazolinyl-S-PCP1 intermediate at the second site (By similarity). When this intermediate is released by the action of a thioesterase, it produces the antifungal antibiotic dihydroaeruginoic acid (Dha or hydroxyphenyl-thiazolinyl-carboxylate) (PubMed:11208777).[UniProtKB:A0A0H2ZGB9]

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