Structural highlights
Function
KDPD_STAA8 Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations (PubMed:21422185, PubMed:26195599). Regulates also capsular polysaccharide production (PubMed:20498265). May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh (PubMed:21422185).[1] [2] [3]
References
- ↑ Zhao L, Xue T, Shang F, Sun H, Sun B. Staphylococcus aureus AI-2 quorum sensing associates with the KdpDE two-component system to regulate capsular polysaccharide synthesis and virulence. Infect Immun. 2010 Aug;78(8):3506-15. PMID:20498265 doi:10.1128/IAI.00131-10
- ↑ Xue T, You Y, Hong D, Sun H, Sun B. The Staphylococcus aureus KdpDE two-component system couples extracellular K+ sensing and Agr signaling to infection programming. Infect Immun. 2011 Jun;79(6):2154-67. PMID:21422185 doi:10.1128/IAI.01180-10
- ↑ Moscoso JA, Schramke H, Zhang Y, Tosi T, Dehbi A, Jung K, Gründling A. Binding of Cyclic Di-AMP to the Staphylococcus aureus Sensor Kinase KdpD Occurs via the Universal Stress Protein Domain and Downregulates the Expression of the Kdp Potassium Transporter. J Bacteriol. 2015 Jul 20;198(1):98-110. PMID:26195599 doi:10.1128/JB.00480-15
