7jlx

Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ (TIR domains)

spinqualitylabelsall models 7jlx, resolution 4.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7jlx is a 4 chain structure with sequence from Nicotiana benthamiana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.6Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ROQ1_NICBE Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).

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