7jrp

Plant Mitochondrial complex SC III2+IV from Vigna radiata

spinqualitylabelsall models 7jrp, resolution 3.80Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7jrp is a 20 chain structure with sequence from Vigna radiata and Vigna radiata var. radiata. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.8Å Ligands: 3PE, CDL, CU, CUA, HEA, HEC, HEM, LYS, MG, PC1, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Mitochondrial complex III (CIII(2)) and complex IV (CIV), which can associate into a higher-order supercomplex (SC III(2)+IV), play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII(2), CIV, and SC III(2)+IV from Vigna radiata determined by single-particle cryoEM. The structures reveal plant-specific differences in the MPP domain of CIII(2) and define the subunit composition of CIV. Conformational heterogeneity analysis of CIII(2) revealed long-range, coordinated movements across the complex, as well as the motion of CIII(2)'s iron-sulfur head domain. The CIV structure suggests that, in plants, proton translocation does not occur via the H channel. The supercomplex interface differs significantly from that in yeast and bacteria in its interacting subunits, angle of approach and limited interactions in the mitochondrial matrix. These structures challenge long-standing assumptions about the plant complexes and generate new mechanistic hypotheses. Atomic structures of respiratory complex III(2), complex IV, and supercomplex III(2)-IV from vascular plants.,Maldonado M, Guo F, Letts JA Elife. 2021 Jan 19;10:e62047. doi: 10.7554/eLife.62047. PMID:33463523 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Cytochrome C 3D structures Cytochrome bc1 3D structures Cytochrome c oxidase 3D structures

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