7k0z

Marsupial T cell receptor Spl_157

spinqualitylabelsall models 7k0z, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7k0z is a 4 chain structure with sequence from Monodelphis domestica. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 3.2Å Ligands: NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed alphabeta and gammadelta T cell receptors (TCRs) are highly diverse antigen receptors that define two evolutionarily conserved T cell lineages. We describe a population of gammamuTCRs found exclusively in non-eutherian mammals that consist of a two-domain (Vgamma-Cgamma) gamma-chain paired to a three-domain (Vmu-Vmuj-Cmu) mu-chain. gammamuTCRs were characterized by restricted diversity in the Vgamma and Vmuj domains and a highly diverse unpaired Vmu domain. Crystal structures of two distinct gammamuTCRs revealed the structural basis of the association of the gammamuTCR heterodimer. The Vmu domain shared the characteristics of a single-domain antibody within which the hypervariable CDR3mu loop suggests a major antigen recognition determinant. We define here the molecular basis underpinning the assembly of a third TCR lineage, the gammamuTCR. The molecular assembly of the marsupial gammamu T cell receptor defines a third T cell lineage.,Morrissey KA, Wegrecki M, Praveena T, Hansen VL, Bu L, Sivaraman KK, Darko S, Douek DC, Rossjohn J, Miller RD, Le Nours J Science. 2021 Mar 26;371(6536):1383-1388. doi: 10.1126/science.abe7070. PMID:33766885 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also T-cell receptor 3D structures

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