7kle
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Ternary structure of Dpo4 bound to N7mG in the template base paired with incoming dCTP
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Structural highlights
FunctionDPO4_SACS2 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. It is involved in translesional synthesis. See AlsoContents | ||||||||||||||||||||
This page was last modified 15:27, 18 October 2023.