7ko8

Cryo-EM structure of the mature and infective Mayaro virus

Loading... Status: waiting for Mol* initialization Structural highlights 7ko8 is a 12 chain structure with sequence from Mayaro virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.4Å Ligands: BMA, MAN, NAG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A0P0BSS5_9VIRU Publication Abstract from PubMed Mayaro virus (MAYV) is an emerging arbovirus of the Americas that may cause a debilitating arthritogenic disease. The biology of MAYV is not fully understood and largely inferred from related arthritogenic alphaviruses. Here, we present the structure of MAYV at 4.4 A resolution, obtained from a preparation of mature, infective virions. MAYV presents typical alphavirus features and organization. Interactions between viral proteins that lead to particle formation are described together with a hydrophobic pocket formed between E1 and E2 spike proteins and conformational epitopes specific of MAYV. We also describe MAYV glycosylation residues in E1 and E2 that may affect MXRA8 host receptor binding, and a molecular "handshake" between MAYV spikes formed by N262 glycosylation in adjacent E2 proteins. The structure of MAYV is suggestive of structural and functional complexity among alphaviruses, which may be targeted for specificity or antiviral activity. Cryo-EM structure of the mature and infective Mayaro virus at 4.4 A resolution reveals features of arthritogenic alphaviruses.,Ribeiro-Filho HV, Coimbra LD, Cassago A, Rocha RPF, Guerra JVDS, de Felicio R, Carnieli CM, Leme L, Padilha AC, Paes Leme AF, Trivella DBB, Portugal RV, Lopes-de-Oliveira PS, Marques RE Nat Commun. 2021 May 24;12(1):3038. doi: 10.1038/s41467-021-23400-9. PMID:34031424 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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