7kyw

Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer

spinqualitylabelsall models 7kyw, resolution 2.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.3Å Ligands: CIT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed Timothy grass pollen is a source of potent allergens. Among them, Phl p 1 and Phl p 5 are thought to be the most important, as a majority of timothy grass-allergic individuals have IgE antibodies directed against these two allergens. The profilin from timothy grass (Phl p 12) has been registered as a minor allergen, with up to 35% of individuals in populations of grass pollen allergic patients showing IgE binding to Phl p 12. Profilins are primarily minor allergens and are known for a high likelihood of co-sensitization as well as cross-reactivity situations caused by their sequence and structure similarity. The crystal structure of Phl p 12.0101 was determined and it revealed that this allergen may form an unusual dimer not previously observed among any profilins. For example, the Phl p 12 dimer has a completely different geometry and interface when compared with the latex profilin (Hev b 8) dimer that has its crystal structure determined. The structure of Phl p 12.0101 is described in the context of allergenic sensitization and allergy diagnostics. Moreover, the structure of the Phl p 12.0101 dimer is discussed, taking into account the production of recombinant allergens and their storage. Crystal structure of timothy grass allergen Phl p 12.0101 reveals an unusual profilin dimer.,O'Malley A, Kapingidza AB, Hyduke N, Dolamore C, Kowal K, Chruszcz M Acta Biochim Pol. 2021 Mar 15;68(1):15-22. doi: 10.18388/abp.2020_5587. PMID:33720678 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Profilin 3D Structures

Proteopedia Page Contributors and Editors (what is this?)

OCA