7lfx

Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+/Ca2+

spinqualitylabelsall models 7lfx, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7lfx is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.1Å Ligands: CA, PCG Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease CNGA1_HUMAN Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry. Function CNGA1_HUMAN Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194] See Also Ion channels 3D structures

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