7lhe

Structure of full-length IP3R1 channel reconstituted into lipid nanodisc in the apo-state

spinqualitylabelsall models 7lhe, resolution 3.30Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7lhe is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.3Å Ligands: PLX, ZN Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ITPR1_RAT Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways (By similarity). See Also Inositol 1%2C4%2C5-Trisphosphate Receptor

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