7lja

Human TRAAK K+ channel FHEIG mutant A198E in a Tl+ bound conductive conformation

spinqualitylabelsall models 7lja, resolution 2.77Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7lja is a 6 chain structure with sequence from Homo sapiens and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.77Å Ligands: CA, TL Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function KCNK4_HUMAN Voltage insensitive, instantaneous, outwardly rectifying potassium channel. Outward rectification is reversed at high external K(+) concentrations (By similarity). Publication Abstract from PubMed TRAAK is a mechanosensitive two-pore domain K(+) (K2P) channel localized to nodes of Ranvier in myelinated neurons. TRAAK deletion in mice results in mechanical and thermal allodynia, and gain-of-function mutations cause the human neurodevelopmental disorder FHEIG. TRAAK displays basal and stimulus-gated activities typical of K2Ps, but the mechanistic and structural differences between these modes are unknown. Here, we demonstrate that basal and mechanically gated openings are distinguished by their conductance, kinetics, and structure. Basal openings are low conductance, short duration, and due to a conductive channel conformation with the interior cavity exposed to the surrounding membrane. Mechanically gated openings are high conductance, long duration, and due to a channel conformation in which the interior cavity is sealed to the surrounding membrane. Our results explain how dual modes of activity are produced by a single ion channel and provide a basis for the development of state-selective pharmacology with the potential to treat disease. Physical basis for distinct basal and mechanically gated activity of the human K(+) channel TRAAK.,Rietmeijer RA, Sorum B, Li B, Brohawn SG Neuron. 2021 Sep 15;109(18):2902-2913.e4. doi: 10.1016/j.neuron.2021.07.009. Epub , 2021 Aug 13. PMID:34390650 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Antibody 3D structures Potassium channel 3D structures

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