7ol1

The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.

spinqualitylabelsall models 7ol1, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7ol1 is a 2 chain structure with sequence from Clostridioides difficile. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.6Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q187A2_CLOD6 Publication Abstract from PubMed In many prokaryotes, the first step of threonine metabolism is catalysed by the enzyme threonine dehydrogenase (TDH), which uses NAD(+) to oxidize its substrate to 2-amino-3-ketobutyrate. The absence of a functional TDH gene in humans suggests that inhibitors of this enzyme may have therapeutic potential against pathogens which are reliant on this enzyme. Here, TDH from Clostridium difficile has been cloned and overexpressed, and the X-ray structure of the apoenzyme form has been determined at 2.6 A resolution. The X-ray structure of L-threonine dehydrogenase from the common hospital pathogen Clostridium difficile.,Adjogatse E, Bennett J, Guo J, Erskine PT, Wood SP, Wren BW, Cooper JB Acta Crystallogr F Struct Biol Commun. 2021 Aug 1;77(Pt 8):269-274. doi:, 10.1107/S2053230X21007135. Epub 2021 Jul 28. PMID:34341193 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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