7on0

Thermus sp. 2.9 DarT in complex with ADP-ribosylated ssDNA

spinqualitylabelsall models 7on0, resolution 1.46Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7on0 is a 2 chain structure with sequence from Thermus sp. 2.9. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.46Å Ligands: AR6 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function DART_THES0 Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system. ADP-ribosylates ssDNA on the second thymidine of the consensus sequence 5'-TNTC-3'; the protein does not auto-modify. Arg-51 is highly flexible, allowing it to assume multiple positions in the crystal structures (PubMed:34408320). Its toxic effect is neutralized by cognate antitoxin DarG (By similarity).[UniProtKB:O53604]

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