7u3s

[2T7+21] Self-assembling tensegrity triangle with two turns of DNA and the sticky end addition of a two-turn linker per axis with R3 symmetry

spinqualitylabelsall models 7u3s, resolution 9.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7u3s is a 6 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 9.5Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed The DNA tensegrity triangle is known to reliably self-assemble into a 3D rhombohedral crystalline lattice via sticky-end cohesion. Here, we expand the library of accessible motifs through (1) covalent extensions of inter-triangle regions and (2) sticky-end coordinated linkages of adjacent triangles with double helical segments using both geometrically symmetric and asymmetric configurations. We report the molecular structures of eighteen self-assembled architectures at resolutions of 3.32-9.32 A; the observed cell dimensions, cavity sizes, and cross-sectional areas agree with theoretical expectations. These data demonstrate that fine control over triclinic and rhombohedral crystal parameters and the customizability of more complex 3D DNA lattices are attainable via rational design. We anticipate that augmented DNA architectures may be fine-tuned for the self-assembly of designer nano-cages, guest-host complexes, and proscriptive 3D nanomaterials, as originally envisioned. Finally, designer asymmetric crystalline building blocks can be seen as a first step toward controlling and encoding information in three dimensions. This article is protected by copyright. All rights reserved. Augmented DNA Nano-Architectures: A Structural Library of 3D Self-Assembling Tensegrity Triangle Variants.,Woloszyn K, Vecchioni S, Ohayon YP, Lu B, Ma Y, Huang Q, Zhu E, Chernovolenko D, Markus T, Jonoska N, Mao C, Seeman NC, Sha R Adv Mater. 2022 Sep 13:e2206876. doi: 10.1002/adma.202206876. PMID:36100349 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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