7usx

Structure of Contracted C. elegans TMC-1 complex

spinqualitylabelsall models 7usx, resolution 3.09Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7usx is a 6 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.09Å Ligands: 3PE, CA, CLR, D12, NAG, PEE, PLM, R16 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TMC1_CAEEL Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex (PubMed:36224384). The MET complex is composed of symmetric dimeric MET channels, each channel comprising two copies of pore-forming ion-conducting transmembrane TMC subunits and auxiliary proteins including the transmembrane inner ear protein/tmie, the calcium-binding protein/calm-1 and arrestin domain protein arrd-6 (PubMed:36224384). Sodium ions are the most permeable, whereas calcium and potassium have lower indices (PubMed:23364694). Sodium-sensor ion channel that acts specifically in salt taste chemosensation. Required for salt-evoked neuronal activity and behavioral avoidance of high concentrations of NaCl.

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