7uzt

Crystal structure of the human astrovirus MLB1 capsid protein spike domain at 1.86-A resolution

spinqualitylabelsall models 7uzt, resolution 1.86Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7uzt is a 3 chain structure with sequence from Astrovirus MLB1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.86Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function B6UYJ1_9VIRU The capsid polyprotein VP90 self-assembles and undergoes a proteolytic cleavage by host caspases to yield the VP70 virions. This immature virion is composed of 180 VP70 subunits with 90 dimeric spikes and displays a T=3 icosahedral symmetry. The mature virion is obtained by further cleavages resulting in three structural proteins VP25, VP27 and VP34. This forms contains only 30 spikes located on the icosahedral 2-fold axes. Plays a role in the attachment to target host cell. This attachment induces virion internalization through clathrin-dependent endocytosis.[RuleBase:RU363102]

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