7w6d

Polyketide cyclase OAC-F24I mutant from Cannabis sativa in complex with olivetolic acid

spinqualitylabelsall models 7w6d, resolution 1.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7w6d is a 2 chain structure with sequence from Cannabis sativa. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.54Å Ligands: 4MX Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function OLIAC_CANSA Publication Abstract from PubMed The therapeutic effects of Delta(9)-tetrahydrocannabinol (Delta(9)-THC) can be enhanced by modifications of the pentyl moiety at C-3. The engineering of Cannabis sativa olivetolic acid cyclase and tetraketide synthase with F24I and L190G substitutions, respectively, in the biosynthesis of Delta(9)-THC serves as a platform for the generation of resorcylic acids up to 6-undecylresorcylic acid. These results provide insights into the development of THC analogs with chemically distinct acyl moieties at C-3. Dual Engineering of Olivetolic Acid Cyclase and Tetraketide Synthase to Generate Longer Alkyl-Chain Olivetolic Acid Analogs.,Lee YE, Nakashima Y, Kodama T, Chen X, Morita H Org Lett. 2022 Jan 14;24(1):410-414. doi: 10.1021/acs.orglett.1c04089. Epub 2021 , Dec 23. PMID:34939812 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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