7wjq

Crystal structure of GSDMB in complex with Ipah7.8

spinqualitylabelsall models 7wjq, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7wjq is a 2 chain structure with sequence from Homo sapiens and Shigella flexneri. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.7Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function IPA7_SHIFL E3 ubiquitin ligase effector protein that interferes with host's ubiquitination pathway (PubMed:30872533). Functions to alter host cell physiology and promote bacterial survival in host tissues (PubMed:30872533). Catalyzes ubiquitination of mouse Nlrp1b allele 1 protein, releasing the cleaved C-terminal part of Nlrp1b, which polymerizes and forms the Nlrp1b inflammasome followed by host cell pyroptosis (PubMed:30872533). See Also Gasdermin 3D structures

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