7wwo

Dimer form of hypothetical protein TTHA1873 from Thermus thermophilus

spinqualitylabelsall models 7wwo, resolution 2.17Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7wwo is a 2 chain structure with sequence from Thermus thermophilus HB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.17Å Ligands: CA Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q5SH57_THET8 Publication Abstract from PubMed The crystal structure of an uncharacterized hypothetical protein, TTHA1873 from Thermus thermophilus, has been determined by X-ray crystallography to a resolution of 1.78 A using the single-wavelength anomalous dispersion method. The protein crystallized as a dimer in two space groups: P43212 and P6122. Structural analysis of the hypothetical protein revealed that the overall fold of TTHA1873 has a beta-sandwich jelly-roll topology with nine beta-strands. TTHA1873 is a dimeric metal-binding protein that binds to two Ca(2+) ions per chain, with one on the surface and the other stabilizing the dimeric interface of the two chains. A structural homology search indicates that the protein has moderate structural similarity to one domain of cell-surface proteins or agglutinin receptor proteins. Red blood cells showed visible agglutination at high concentrations of the hypothetical protein. Structure of the hypothetical protein TTHA1873 from Thermus thermophilus.,Yuvaraj I, Chaudhary SK, Jeyakanthan J, Sekar K Acta Crystallogr F Struct Biol Commun. 2022 Sep 1;78(Pt 9):338-346. doi:, 10.1107/S2053230X22008457. Epub 2022 Aug 30. PMID:36048084 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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