7x2u

Structure of a human NHE3-CHP1 complex in the autoinhibited state

spinqualitylabelsall models 7x2u, resolution 3.20Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7x2u is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.2Å Ligands: 85R, PGT Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Disease SL9A3_HUMAN Congenital sodium diarrhea;Cystic fibrosis. The disease is caused by variants affecting the gene represented in this entry. Function SL9A3_HUMAN Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773).[UniProtKB:G3X939]

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