Structural highlights
Function
SSZ1_YEAST Component of the ribosome-associated complex (RAC), a heterodimeric chaperone complex involved in regulation of accurate translation termination and in folding or maintaining nascent polypeptides in a folding-competent state. RAC stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones SSB1/SSB2 that bind to the nascent polypeptide chain. SSZ1 is required for ZUO1 to function efficiently as a J-protein for SSB1/SSB2. Also involved in pleiotropic drug resistance by post-translational activation of transcription factor PDR1.[1] [2] [3]
References
- ↑ Hundley H, Eisenman H, Walter W, Evans T, Hotokezaka Y, Wiedmann M, Craig E. The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain. Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4203-8. PMID:11929993 doi:10.1073/pnas.062048399
- ↑ Rakwalska M, Rospert S. The ribosome-bound chaperones RAC and Ssb1/2p are required for accurate translation in Saccharomyces cerevisiae. Mol Cell Biol. 2004 Oct;24(20):9186-97. PMID:15456889 doi:https://dx.doi.org/10.1128/MCB.24.20.9186-9197.2004
- ↑ Huang P, Gautschi M, Walter W, Rospert S, Craig EA. The Hsp70 Ssz1 modulates the function of the ribosome-associated J-protein Zuo1. Nat Struct Mol Biol. 2005 Jun;12(6):497-504. Epub 2005 May 22. PMID:15908962 doi:https://dx.doi.org/10.1038/nsmb942
