7x41

Crystal structure of chlorotoxin, a glioma specific scorpion toxin

spinqualitylabelsall models 7x41, resolution 1.15Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7x41 is a 1 chain structure with sequence from Leiurus quinquestriatus quinquestriatus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.15Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function CTXL_LEIQU This toxin binds to the surface of glioma cells, and inhibits their proliferation without having effects on normal brain cells. In this context, this toxin has been described as a chloride channel inhibitor (probably ClC-3/CLCN3) by causing its internalization via caveolae (PubMed:16520829). It has also been described to selectively interact with MMP2 (in complex with MT1-MMP (MMP14) and TIMP2), to inhibit its enzymatic activity and to decrease its presence at the cell surface (PubMed:12454020).

Proteopedia Page Contributors and Editors (what is this?)

OCA