7xao

Crystal structure of thioredoxin 1

spinqualitylabelsall models 7xao, resolution 1.45Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xao is a 2 chain structure with sequence from Acinetobacter baumannii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.45Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function V5VGM8_ACIBA Publication Abstract from PubMed Thioredoxin (Trx) is a central component of the redox control system that maintains the redox homeostasis critical for organism survival. Owing to its central role in survival, Trx is a prospective target for novel antimicrobial agents. Herein, we report a 1.45 A high-resolution structure of Trx1 of Acinetobacter baumannii (abTrx1), an antibiotic-resistant pathogenic superbug. Although abTrx1 exhibited the canonical Trx fold, which consists of a four-stranded beta-sheet surrounded by four alpha-helices, structural differences were detected in the loop forming the C-X-X-C redox center and the C-terminal. The unique CAPC sequence of the C-X-X-C motif in the abTrx1 redox center was characterized by mutagenesis. This study contributes to the field of drug designing against superbugs. High-resolution crystal structure of Acinetobacter baumannii thioredoxin 1.,Chang YJ, Park HH Biochem Biophys Res Commun. 2022 Jun 11;608:1-7. doi: 10.1016/j.bbrc.2022.03.134. , Epub 2022 Mar 28. PMID:35378360 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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