7xiv

Structural insight into the interactions between Lloviu virus VP30 and nucleoprotein

spinqualitylabelsall models 7xiv, resolution 2.50Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xiv is a 2 chain structure with sequence from Lloviu cuevavirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.498Å Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function G8EFI6_LLOVA G8EFI1_LLOVA Publication Abstract from PubMed The family Filoviridae comprises many notorious viruses, such as Ebola virus (EBOV) and Marburg virus (MARV), that can infect humans and nonhuman primates. Lloviu virus (LLOV), a less well studied filovirus, is considered a potential pathogen for humans. The VP30 C-terminal domain (CTD) of these filoviruses exhibits nucleoprotein (NP) binding and plays an essential role in viral transcription, replication and assembly. In this study, we confirmed the interactions between LLOV VP30 CTD and its NP fragment, and also determined the crystal structure of the chimeric dimeric LLOV NP-VP30 CTD at 2.50 A resolution. The structure is highly conserved across the family Filoviridae. While in the dimer structure, only one VP30 CTD binds the NP fragment, which indicates that the interaction between LLOV VP30 CTD and NP is not strong. Our work provides a preliminary model to investigate the interactions between LLOV VP30 and NP and suggests a potential target for anti-filovirus drug development. Structural insights into the interactions between lloviu virus VP30 and nucleoprotein.,Sun W, Luan F, Wang J, Ma L, Li X, Yang G, Hao C, Qin X, Dong S Biochem Biophys Res Commun. 2022 Aug 6;616:82-88. doi: , 10.1016/j.bbrc.2022.05.059. Epub 2022 May 20. PMID:35649303 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Nucleoprotein 3D structures

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