7xkm

Crystal structure of DNA-Ag(I) rod comprising a one-dimensional array of 11 silver ions

spinqualitylabelsall models 7xkm, resolution 2.79Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Structural highlights 7xkm is a 4 chain structure with sequence from Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 2.79Å Ligands: AG, BRU Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed DNA/RNA duplexes containing metal-ion-mediated base pairs (metallo-base pairs) have potential applications in developing nucleic acid-based nanodevices and genetic code expansion. Many metallo-base pairs are formed within duplexes stabilized by Watson-Crick base pairs. Recently, the crystal structure of an Ag(I) -DNA nanowire with an uninterrupted one-dimensional silver array was determined. Here, we present a new DNA helical wire, the "Ag(I) -DNA rod", containing an uninterrupted array of 11 Ag(I) ions. The Ag(I) -DNA rod consisted of only C-Ag(I) -C, G-Ag(I) -G, G-Ag(I) -5-bromouracil ((Br) U), and (Br) U-Ag(I) -(Br) U metallo base pairs, with no Watson-Crick pairs. The Ag(I) -DNA rods were connected by non-canonical G-G pairs in crystals. Notably, data from our absorbance, circular dichroism, nuclear magnetic resonance, and mass spectrometry analyses suggested that the Ag(I) -DNA rods formed in solution, as well as within crystals. A Novel Ag(I) -DNA Rod Comprising a One-Dimensional Array of 11 Silver Ions within a Double Helical Structure.,Atsugi T, Ono A, Tasaka M, Eguchi N, Fujiwara S, Kondo J Angew Chem Int Ed Engl. 2022 Aug 1;61(31):e202204798. doi: , 10.1002/anie.202204798. Epub 2022 Jun 21. PMID:35641885 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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