7xx8
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Solution structure of RRM1 of Human SART3
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Structural highlights
DiseaseSART3_HUMAN Defects in SART3 are the cause of disseminated superficial actinic porokeratosis type 1 (DSAP1) [MIM:175900. DSAP1 is an autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin.[1] FunctionSART3_HUMAN Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication.[2] References
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This page was last modified 05:22, 25 September 2024.